Fentanyl is a weak substrate of CYP2D6, CYP3A4, and P glycoprotein, and concurrent use of fentanyl and a kinase inhibitor such as imatinib a CYP3A4 inhibitor or nilotinib CYP3A4 and P glycoprotein inhibitor can increase sedation in patients 79 priligy generic It s devastating to hear these stories but I m so glad you shared with us